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KMID : 0923620160160060330
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Immune Network
2016 Volume.16 No. 6 p.330 ~ p.336
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Regulatory T Cells in Hepatitis B and C Virus Infections
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Jung Min-Kyung
Shin Eui-Cheol
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Abstract
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Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that establish chronic persistent infection by effectively escaping the host immune response and can cause immune-mediated liver injury. It has recently become apparent that regulatory T (Treg) cells, specifically CD4+CD25+Foxp3+ Treg cells, modulate viral diseases by suppressing antiviral immune responses and regulating inflammatory host injury. The roles of Treg cells in HBV and HCV infections range from suppressing antiviral T cell responses to protecting the liver from immune-mediated damage. This review describes Treg cells and subpopulations and focuses on the roles of these cells in HBV and HCV infections.
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KEYWORD
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Regulatory T cell, Hepatitis B virus, Hepatitis C virus
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